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IMBM Lab

Designing Materials that Heal, Modulate, and Transform

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Before MIT

Publications

2025 Antibody labeling with FITC facilitates controlled release from peptide hydrogels bearing Fc-binding motifs

Journal Article

T.L. Lopez-Silva, J.P. Schneider. Journal of Peptide Science. 2025, 31(7), e70032.
  • BibTex Key
  • Authors Lopez Silva TL | Schneider J
  • Tags Drug Delivery | Hydrogel

    2025 Elucidation and prevention of an unexpected methylamine byproduct formed during trifluoroacetic acid-mediated side chain deprotection of azido-containing peptides

    Journal Article

    Y. Xie, T.L. Lopez-Silva, M.A. Dyba, T. Grkovic, J.P. Schneider. Int J Pept Res Ther, 2025, 31, 67. https://doi.org/10.1007/s10989-025-10726-x

    • BibTex Key Xie Y,Lopez Silva TL,Grkovic Tanja,Dyba M,Schneider J2025
    • Authors Dyba M | Grkovic Tanja | Lopez Silva TL | Schneider J | Xie Y
    • Tags Peptide Synthesis
    • DOI Number 10.1007/s10989-025-10726-x

      2025 Modulating Neutrophil Extracellular Trap Formation In Vivo with Locoregional Precision using Differently Charged Self-Assembled Hydrogels

      Journal Article

      T.L. Lopez-Silva, C.F. Anderson, J.P. Schneider. ACS Cent. Sci. 2025, 11, 3, 465-478. https://doi.org/10.1021/acscentsci.4c02198. Previously: bioRxiv 2024.08.16.608275. https://doi.org/10.1101/2024.08.16.608275

      • BibTex Key
      • Authors Anderson CF | Lopez Silva TL | Schneider J
      • Tags Host response | Hydrogel | Immune Response | Inflammation | NETs | Neutrophils
      • DOI Number acscentsci.4c02198

        2024 Ultrasound and x-ray imageable poloxamer-based hydrogel for loco-regional therapy delivery in the liver

        Journal Article

        J.F. Delgado, J.W. Owen, W.F. Pritchard, N.A. Varble, T.L. Lopez-Silva, A.S. Mikhail, A. Arrichiello, T. Ray, R. Morhard, T. Borde, L. Saccenti, S. Xu, J. Rivera, J.P. Schneider, J.W. Karanian, B.J. Wood. Scientific Reports. 2024 14, 20455. https://doi.org/10.1038/s41598-024-70992-5

        • BibTex Key
        • Authors
        • Tags Drug Delivery | Hydrogel | Image-guided delivery
        • DOI Number 10.1038/s41598-024-70992-5

          2024 X-ray imageable, drug-loaded hydrogel that forms at body temperature for image-guided, needle-based locoregional drug delivery

          Journal Article

          J.F. Delgado, W.F. Pritchard, N. Varble, T.L. Lopez-Silva, A. Arrichiello, A.S. Mikhail, R. Morhard, T. Ray, M.M. Havakuk, A. Nguyen, T. Borde, J.W. Owen, J.P. Schneider, J.W. Karanian, B.J. Wood. Scientific Reports. 2024 14, 13352. https://doi.org/10.1038/s41598-024-64189-z

          • BibTex Key
          • Authors
          • Tags Drug Delivery | Hydrogel | Image-guided delivery
          • DOI Number 10.1038/s41598-024-64189-z

            2024 Impact of Glycosylation on Self-Assembled Peptide Hydrogels

            Journal Article

            T.L. Lopez-Silva, T.D. Samdin, C.F. Anderson, D.R. Bell, E. Suarez Alvarez, W.K. Kasprzak, J. Shi, J.P. Schneider. Chemistry of Materials. 2024, 36 (8), 3861-3874. https://doi.org/10.1021/acs.chemmater.4c00291

            • BibTex Key Lopez Silva TL,Samdin TD,Anderson CF,Bell DR,Suarez alvarez E,Kasprzak WK,Shi J,Schneider J2024
            • Authors Anderson CF | Bell DR | Kasprzak WK | Lopez Silva TL | Samdin TD | Schneider J | Shi J | Suarez alvarez E
            • Tags Hydrogel | Materials Science | Self-assembly
            • DOI Number 10.1021/acs.chemmater.4c00291

              2022 Hydrophilic Azide-Containing Amino Acid to Enhance the Solubility of Peptides for SPAAC Reactions

              Journal Article

              Y. Xie*, T.L. Lopez-Silva*, J.P. Schneider. Organic Letters. 2022, 24, 40, 7378–7382.  https://doi.org/10.1021/acs.orglett.2c02906

              * Co-first authorship

              • BibTex Key Xie Y,Lopez Silva TL,Schneider J2022
              • Authors Lopez Silva TL | Schneider J | Xie Y
              • Tags Click Chemistry | Peptide Synthesis | SPAAC
              • DOI Number 10.1021/acs.orglett.2c02906

                2022 A Combined Conduit-Bioactive Hydrogel Approach for Regeneration of Transected Sciatic Nerves

                Journal Article

                C.S.E. Lai, V. Leyva-Aranda, V.H. Kong, T.L. Lopez-Silva, A.C. Farsheed, C.D. Cristobal, J. W.R. Swain, H.K. Lee, J.D. Hartgerink. ACS Applied Bio Materials. 2022, 5, 10, 4611–4624.  https://doi.org/10.1021/acsabm.2c00132

                • BibTex Key Lai CSE,Leyva-Aranda V,Kong VH,Lopez Silva TL,Farsheed AC,Cristobal CD,Swain JWR,Lee HK,Hartgerink JD2022
                • Authors Cristobal CD | Farsheed AC | Hartgerink JD | Kong VH | Lai CSE | Lee HK | Leyva-Aranda V | Lopez Silva TL | Swain JWR
                • Tags Host response | Hydrogel | Nerve Regeneration
                • DOI Number 10.1021/acsabm.2c00132

                  2022 Direct observation of peptide hydrogel self-assembly

                  Journal Article

                  Z.C. Adams, E. J. Olson, T.L. Lopez-Silva, Z. Lian, A.Y. Kim, M. Holcomb, J. Zimmermann, R. Adhikary, P.E. Dawson. Chemical Science. 2022, 13, 34, 10020-10028.  https://doi.org/10.1039/D1SC06562A

                  • BibTex Key Adams ZC,Olson EJ,Lopez Silva TL,Lian Z,Kim AY,Holcomb M,Zimmermann J,Adhikary R,Dawson PE2022
                  • Authors Adams ZC | Adhikary R | Dawson PE | Holcomb M | Kim AY | Lian Z | Lopez Silva TL | Olson EJ | Zimmermann J
                  • Tags Self-assembly
                  • DOI Number 10.1039/D1SC06562A

                    2021 From structure to application: Progress and opportunities in peptide materials development

                    Journal Article

                    T.L. Lopez-Silva, J.P. Schneider. Current Opinion in Chemical Biology. 2021, 64, 131-144. https://doi.org/10.1016/j.cbpa.2021.06.006

                    • BibTex Key Lopez Silva TL,Schneider Joel2021
                    • Authors Lopez Silva TL | Schneider Joel
                    • Tags Hydrogels | Review | Self-assembly
                    • DOI Number 10.1016/j.cbpa.2021.06.006

                      2021 Self-assembling multidomain peptide hydrogels accelerate peripheral nerve regeneration after crush injury

                      Journal Article

                      T.L. Lopez-Silva*, C.D. Cristobal*, C.S.E. Lai, V. Leyva-Aranda, H.K. Lee, J.D. Hartgerink. Biomaterials. 2021, 265, 120401. https://doi.org/10.1016/j.biomaterials.2020.120401

                      * Co-first authorship

                      • BibTex Key Cristobal CD,Hartgerink JD,Lai CSE,Lee HK,Leyva-Aranda V,Lopez Silva TL2021
                      • Authors Cristobal CD | Hartgerink JD | Lai CSE | Lee HK | Leyva-Aranda V | Lopez Silva TL
                      • Tags Host response | Hydrogel | Nerve Regeneration
                      • DOI Number 10.1016/j.biomaterials.2020.120401

                        2020 Chemical functionality of Multidomain Peptide Hydrogels governs early host immune response

                        Journal Article

                        T.L. Lopez-Silva, D.G. Leach, A. Azares, I. Li, D.G. Woodside, J.D. Hartgerink.  Biomaterials. 2020, 231, 119667. https://doi.org/10.1016/j.biomaterials.2019.119667

                        • BibTex Key
                        • Authors Azarez A | Hartgerink JD | Leach DG | Li I | Lopez Silva TL | Woodside DG
                        • Tags Host response | Hydrogel
                        • DOI Number 10.1016/j.biomaterials.2019.119667

                          2019 Drug-Mimicking Nanofibrous Peptide Hydrogel for Inhibition of Inducible Nitric Oxide Synthase (iNOS)

                          Journal Article

                          D.G. Leach, J.M. Newton, M.A. Florez, T.L. Lopez-Silva, A.A Jones, S. Young, A.G. Sikora, J.D. Hartgerink. ACS Biomaterials Science & Engineering. 2019, 5,12,6755-6765. https://doi.org/10.1021/acsbiomaterials.9b01447

                          • BibTex Key Leach DG,Newton JM,Florez MA,Lopez Silva TL,Jones AA,Sikora G,Young S,Hartgerink JD2019
                          • Authors Florez MA | Hartgerink JD | Jones AA | Leach DG | Lopez Silva TL | Newton JM | Sikora G | Young S
                          • Tags Drug Delivery | Drug-mimicking | Hydrogel
                          • DOI Number 10.1021/acsbiomaterials.9b01447

                            2019 Self-Assembling Multidomain Peptides: Design and Characterization of Neutral Peptide-Based Materials with pH and Ionic Strength Independent Self-Assembly

                            Journal Article

                            T.L. Lopez-Silva, D.G. Leach, I. Li, X. Wang, J.D. Hartgerink.  ACS Biomaterials Science & Engineering. 2019, 5, 2, 977-985. https://doi.org/10.1021/acsbiomaterials.8b01348

                            • BibTex Key Hartgerink JD,Leach DG,Li I,Lopez Silva TL,Wang X2019
                            • Authors Hartgerink JD | Leach DG | Li I | Lopez Silva TL | Wang X
                            • Tags Cell culture | Host response | Hydrogel | Self-assembly
                            • DOI Number 10.1021/acsbiomaterials.8b01348

                              2018 STINGel: Controlled release of a cyclic dinucleotide for enhanced cancer immunotherapy

                              Journal Article

                              D.G. Leach, N. Dharmaraj, S.L. Piotrowski, T.L. Lopez-Silva, Y.L. Lei, G. Sikora, S. Young, J.D. Hartgerink. Biomaterials. 2018, 163, 67-75. https://doi.org/10.1016/j.biomaterials.2018.01.035

                              • BibTex Key Leach DG,Dharmaraj N,Piotrowski SL,Lopez Silva TL,Lei YL,Sikora G,Young S,Hartgerink JD2018
                              • Authors Dharmaraj N | Hartgerink JD | Leach DG | Lei YL | Lopez Silva TL | Piotrowski SL | Sikora G | Young S
                              • Tags Cancer | Drug Delivery | Hydrogel | Immunotherapy
                              • DOI Number 10.1016/j.biomaterials.2018.01.035

                                2018 Nanofibrous peptide hydrogel elicits angiogenesis and neurogenesis without drugs, proteins, or cells

                                Journal Article

                                A.N. Moore, T.L. Lopez-Silva, N. C. Carrejo, C. Origel, I. Li, J.D. Hartgerink. Biomaterials. 2018, 161, 154-163. https://doi.org/10.1016/j.biomaterials.2018.01.033

                                • BibTex Key Carrejo NC,Hartgerink JD,Li I,Lopez Silva TL,Moore AM,Origel C2018
                                • Authors Carrejo NC | Hartgerink JD | Li I | Lopez Silva TL | Moore AM | Origel C
                                • Tags Angiogenesis | Host response | Hydrogel
                                • DOI Number j.biomaterials.2018.01.033

                                  2018 Multidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Mice.

                                  Journal Article

                                  N.C. Carrejo, A.N. Moore, T.L. Lopez-Silva, D.G. Leach, I. Li, D.R. Walker, J.D. Hartgerink.  ACS Biomaterials Science & Engineering. 2018, 4, 4, 1386-1396. https://doi.org/10.1021/acsbiomaterials.8b00031

                                  • BibTex Key Carrejo NC,Moore AM,Lopez Silva TL,Leach DG,Li I,Walker DR,Hartgerink JD2018
                                  • Authors Carrejo NC | Hartgerink JD | Leach DG | Li I | Lopez Silva TL | Moore AM | Walker DR
                                  • Tags Hydrogel | MDP | Wound healing
                                  • DOI Number acsbiomaterials.8b00031

                                    2017 Two-phase amorphous-amorphous solid drug dispersion with enhanced stability, solubility and bioavailability resulting from ultrasonic dispersion of an immiscible system

                                    Journal Article

                                    L.M. Martinez, M. Videa, T.L. Lopez-Silva, S. Castro, A. Caballero, V.J. Lara-Diaz, F. Casterona-Torres. European Journal Pharmaceutics and Biopharmaceutics. 2017, 119, 243-252. https://doi.org/10.1016/j.ejpb.2017.06.021

                                    • BibTex Key Martinez LM,Videa M,Lopez Silva TL,Castro S,Caballero A,Lara Diaz V,Castorena Torres FTL2017
                                    • Authors Caballero A | Castorena Torres FTL | Castro S | Lara Diaz V | Lopez Silva TL | Martinez LM | Videa M
                                    • Tags Amorphous solids | Drug solubility
                                    • DOI Number 10.1016/j.ejpb.2017.06.021

                                      2014 Synthesis of bridged oxafenestranes from pleuromutilin

                                      Journal Article

                                      R.W. Hicklin, T.L. Lopez-Silva, P.J. Hergenrother. Angewandte Chemie International Edition. 2014, 53(37), 9880-9883. https://doi.org/10.1002/anie.201404765

                                      • BibTex Key Hicklin RW,Lopez Silva TL,Hergenrother2014
                                      • Authors Hergenrother | Hicklin RW | Lopez Silva TL
                                      • Tags Natural Products | Synthesis
                                      • DOI Number 10.1002/anie.201404765